Tatiana Costa

Tatiana is a pharmacist with over 20 years of experience inMolecular Genetics, Cell Biology, and Biochemistry of Trypanosomatids. She carriedout four postdoctoral researches in these areas, and has expertise inidentifying virulence factors, elucidating the molecular mechanisms thatpromote the infectivity and survival of protozoa, and assisting in thedevelopment of new intervention strategies and drugs for the treatment ofleishmaniasis and Chagas disease. Tatiana has also ample experience withCRISPR-Cas9 gene editing, genetic validation/modification of peptidases, with aparticular focus on natural peptidase inhibitors for the development ofanti-parasite therapies.

Education

Post-doctoral researches fromFundação de Amparo à Pesquisa do Estado do Rio de Janeiro – FAPERJ (2015);

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES (2020);

Global Challenge Research Found – GCRF (2022); and Drugs for Neglected Diseasesinitiative – DNDi (ongoing).

P.hD. in Sciences from Institutode Biofísica Carlos Chagas Filho da Universidade Federal do Rio de Janeiro(UFRJ).

M.Sc. in Biological Sciences(Biophysics) from Instituto de Biofísica Carlos Chagas Filho da UniversidadeFederal do Rio de Janeiro (UFRJ).

B.Sc. in Industrial Pharmacy fromUniversidade Federal do Rio de Janeiro (UFRJ).

Publications

Costa TFR, Catta-Preta CMC, Goundry A, Carvalho DB, RodriguesNS, Vivarini AC, de Abreu MF, Reis FCG, Lima APCA. The ecotin-like peptidase inhibitor ofTrypanosoma cruzi prevents TMPRSS2-PAR2-TLR4 crosstalk downmodulating infectionand inflammation. FASEB J. 2024 Mar31;38(6):e23566. doi: 10.1096/fj.202302091RR

‍Costa TFR, Goundry A, Morrot A, Grab DJ, Mottram JC, LimaAPCA. Trypanosoma brucei rhodesiense Inhibitor of CysteinePeptidase (ICP) Is Required for Virulence in Mice and to Attenuate theInflammatory Response. Int J Mol Sci.2022 Dec 30;24(1):656. doi: 10.3390/ijms24010656

Novaes R, Costa TFR, Goundry AL, Verçoza BRF, Rodrigues JCF,Godinho JLP, Reis FCG, Morrot A, Lima APCA. Bone marrow granulocytes downregulate IL-1β and TNF production and themicrobicidal activity of inflammatory macrophages. Biochem Cell Biol. 2022 Jun1;100(3):246-265. doi: 10.1139/bcb-2021-0460.

Dias BT, Goundry A, Vivarini AC, Costa TFR,Mottram JC, Lopes UG, Lima APCA. Toll-Like Receptor- and Protein KinaseR-Induced Type I Interferon Sustains Infection of Leishmania donovani inMacrophages. Front Immunol. 2022 Jan 28;13:801182. doi:10.3389/fimmu.2022.801182. eCollection 2022.

Levy DJ, Goundry A, Laires RSS, Costa TFR,Novo CM, Grab DJ, Mottram JC, Lima APCA. Role of the inhibitor of serinepeptidase 2 (ISP2) of Trypanosoma bruceirhodesiense in parasite virulence and modulation of the inflammatoryresponses of the host. PLoS Negl Trop Dis. 2021 Jun 21;15(6):e0009526. doi:10.1371/journal.pntd.0009526.

Silva RCMC, Fox EGP, Gomes FM, Feijó DF, RamosI, Koeller CM, Costa TFR, Rodrigues NS, Lima AP, Atella GC, Miranda K,Schoijet AC, Alonso GD, de Alcântara Machado E, Heise N. Venom alkaloidsagainst Chagas disease parasite: search for effective therapies. Sci Rep. 2020Jun 30;10(1):10642. doi: 10.1038/s41598-020-67324-8.

Pereira MG, Visbal G, Costa TFR, FrasesS, de Souza W, Atella G, Cunha-E-Silva N. Trypanosomacruzi epimastigotes store cholesteryl esters in lipid droplets aftercholesterol endocytosis. Mol BiochemParasitol. 2018 Sep;224:6-16. doi: 10.1016/j.molbiopara.2018.07.004.

‍Costa, Tatiana Ferreira Rocha, Lima, AnaPaula. Natural cysteine protease inhibitors inprotozoa: Fifteen years of the chagasin family. Biochimie. 2016Mar;122:197-207.

Camila M. Adade,Ana Lúcia O. Carvalho, Marcelo A. Tomaz, TatianaF. R. Costa, Joseane L. Godinho, Paulo A. Melo, Ana Paula C. A. Lima,Juliany C. F. Rodrigues, Russolina B. Zingali,2 and Thaïs Souto-Padrón. Crovirin, a Snake Venom Cysteine-Rich SecretoryProtein (CRISP) with Promising Activity against Trypanosomes and Leishmania.PLoS Negl Trop Dis. 2014 Oct 16;8(10):e3252.

Lima, Ana Paula,Reis, Flavia C. G., Costa, TatianaFerreira Rocha. Cysteine peptidase inhibitors in trypanosomatid parasites.Curr Med Chem. 2013;20(25):3152-73.

‍Costa, Tatiana Ferreira Rocha, Reis, Flavia C.G., Lima, Ana Paula. Substrateinhibition and allosteric regulation by heparan sulfate of Trypanosoma bruceicathepsin L. Biochim Biophys Acta. 2012 Mar;1824(3):493-501.

Nogueira de Melo, Ana Cristina; de Souza, Edilma Paraguai; Elias, CamilaGuarany Ramalho ; dos Santos, André Luis Souza; Branquinha, Marta Helena; dÁvila-Levy, Cláudia Masini; dos Reis, Flávia Coelho Garcia; Costa, TatianaFerreira Rocha; de Araujo Lima, Ana Paula Cabral; de Souza Pereira, MirianCláudia. Detection ofmatrix metallopeptidase-9-like proteins in Trypanosomacruzi. Experimental Parasitology, v. 125, p. 256-263, 2010.

dos Reis, F; Smith, B; Santos, C; Costa,T.F.R.; Scharfstein, J; Coombs, G; Mottram, J; Lima, A. P. The role ofconserved residues of chagasin in the inhibition of cysteine peptidases. FEBSLetters, v. 582, p. 485-490, 2008.

Reis, Flavia C.G.; Costa, Tatiana F. R.; Sulea, Traian; Mezzetti,Alessandra; Scharfstein, Julio; Brömme, Dieter; Ménard, Robert; Lima, Ana PaulaC. A. The propeptide of cruzipain: a potent selective inhibitor of thetrypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsinF. The FEBS Journal, v. 274, p. 1224-1234, 2007.

Languages

Portuguese
English
Spanish